Dr Henrietta Ewart has left her role within the government and intends to retire.
Dr Ewart took up the role of Director of Public Health in December 2016 after serving as interim Director for 18 months.
It comes after David Ashford announced he was stepping down as Treasury Minister and Department of Health and Social Care CEO Karen Malone left her position.
Interim Chief Secretary Caldric Randall says the role of Director of Public Health will be advertised in due course, and thanks Dr Ewart for her commitment and expertise.
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