The Department of Infrastructure says it's banning cyclists from using the Mountain Road during the Festival of Motorcycling later this month.
Unlike in TT, the road remains two-way for the fortnight-long festival which gets underway on Saturday, August 19.
During this year's TT festival, police spoke to cyclists who were planning to tackle the route in an organised ride on the Friday of practice week.
Road Safety Manager Gordon Edwards says it's about making sure cyclists and other road users aren't at risk:
Illegal immigrant turned back at Manx border can't stay in UK
Bank scammers warning as calls target Island residents
Island to extend UK VAT cut on power, says Treasury Minister
Woman thanks mystery van driver after daring sea rescue
Stay off damaged slipway in Laxey, says local authority
MHK sues attorney general and returning officer over election votes
Islanders reminded to keep challenging domestic abuse beyond October