The Steam Packet Company says two TT sailings to Liverpool will be from Heysham instead.
Pier Head operator Global Ports Holding says the sailings on June 2 and 3 won't be able to use the Mersey landing stage.
The Manannan will operate the crossings, which will take two and a half hours hours, rather than the usual three hours from Liverpool.
The company says coaches will take foot passengers from Liverpool to Heysham and vice versa.
Church unveils plans to modernise facilities
Are Mountain Road closures harming Ramsey?
No whey! Creamery says goodbye to much-loved butter
Roofing Outlaw plans Isle of Man franchise
Can you help find fly-tippers?
Aldi and Lidl on Summerland site?
Corrin leaps to silver and breaks national record at British Indoor Championships
Gambling Supervision to look at renewing betting office licenses