The Steam Packet Company says two TT sailings to Liverpool will be from Heysham instead.
Pier Head operator Global Ports Holding says the sailings on June 2 and 3 won't be able to use the Mersey landing stage.
The Manannan will operate the crossings, which will take two and a half hours hours, rather than the usual three hours from Liverpool.
The company says coaches will take foot passengers from Liverpool to Heysham and vice versa.
Ramsey's cannabis club to shut as business relocates
Nearly 1 in 7 affected by poverty, says report
Soggy bottoms expected at Bake Off musical!
Castletown's square reopens to traffic this week
Boy's murder trial gets underway today
Mum's plea to parents after son attacked at football
Company issues advice over mobile network upgrade
Eating disorder support group to host first meeting