Police say the Mountain Road will be shut until around 11pm.
What's being described as "a serious crash" on the route just before 5pm meant officers closed it while they dealt with the incident.
It's currently closed between the Creg ny Baa Back Road and Brandywell.
An emergency road closure order says it'll be closed until 11pm, or until the scene has been cleared.
Yoga studio applies for sign permission
A yoga studio in Douglas has applied for retrospective planning permission for signs outside the building.
Yacht club worries over lifeboat retirement
A yacht club based in the south of the Island says it has reservations about Port St Mary losing one of its lifeboats.
One nuisance cyclist ticketed in more than three years
Douglas Council says it's had 13 complaints about cyclists in almost four years.
New ministerial post created by chief minister
The Isle of Man has a new ministerial job - and a minister to go with it.
Huge floating book fair to arrive in Douglas next month
The world's largest floating bookshop will be in Douglas for almost a fortnight next month.
Stay safe for Hop Tu Naa tonight
Police are asking trick or treaters to make sure they can be seen tonight.
Special Olympics fundraiser needs you
A organisation for athletes with learning disabilities has raised more than £17,000 to compete at a global competition in Chile next year.
Peel ready for bonfire and fireworks later
Peel kicks off the Island's bonfire night fun tonight with its fireworks display.
