Police say the Mountain Road will be shut until around 11pm.
What's being described as "a serious crash" on the route just before 5pm meant officers closed it while they dealt with the incident.
It's currently closed between the Creg ny Baa Back Road and Brandywell.
An emergency road closure order says it'll be closed until 11pm, or until the scene has been cleared.
Last chance to become next TT's charity partner
Today's your last chance to apply to become next year's official TT charity partner.
No gas price hike after regulator review
The Island's regulator says there'll be no gas price rises until at least the end of the year after a review.
Cafe hits back after staff abused
A café in the south of the Island has hit back after a man abused two young members of staff during their first day on the job.
Online appointments being considered by sexual health clinic
Health Minister Claire Christian says the Island's sexual health clinic gets around 300 phone calls a week - and Manx Care is considering an online appointments system.
Treasury can’t say how much is made from medicinal cannabis
Treasury Minister Chris Thomas says he doesn't know how much money medicinal cannabis has put in the government's coffers.
Road closures planned for tin baths this weekend
One of the highlights of Castletown's summer calendar takes place this Saturday, with a number of road closures planned for the event.
DOI has no junction safety concerns over Iceland plans
The Department of Infrastructure says it doesn't have any safety concerns about a junction near a proposed new Iceland store in Braddan.
LegCo to face questions in this morning's sitting
Members of the Legislative Council will face a total of seven questions when they sit later.
