Police say the Mountain Road will be shut until around 11pm.
What's being described as "a serious crash" on the route just before 5pm meant officers closed it while they dealt with the incident.
It's currently closed between the Creg ny Baa Back Road and Brandywell.
An emergency road closure order says it'll be closed until 11pm, or until the scene has been cleared.
Expanded Superdrug opens next week!
A city centre store in Douglas says it's looking forward to doubling in size when it opens next week.
No-fly zone for Red Arrows TT display
Trying to join in with the Red Arrows this TT could see you spending five years in jail.
Douglas prom re-opens after crash
Police say part of Douglas has now re-opened following a crash this morning.
New bar and restaurant to open this weekend
The Island's newest bar and restaurant will throw open its doors this weekend.
Over £30k paid out for pothole damage since 2023
A total of 48 claims were made for damage from potholes in the past year.
Rapist to appeal his sentence this week
A rapist who was jailed for almost 19 years after carrying out a sustained attack on a woman is to appeal his sentence.
Horse trams suspended by promenade crash
Douglas Bay Horse Tramway says it's suspended tram services until further notice because of a crash this morning.
Colourful coins to be released to celebrate national parks
The Treasury is set to release a new set of colour coins showing off national parks in the UK and the Isle of Man.
