Part of Breakwater Road in Port Erin is to close for around a year as work gets underway to redevelop the former Marine Biological Station.
In September, Delgatie Limited was given permission to transform the site into 58 flats, 14 tourist apartments, an exhibition space and a pub/restaurant.
The first phase of the works will see the road layout changed to accommodate the new facilities, and the road will shut from December 2 until November 28 next year.
One-way restrictions on the lower section of Breakwater Road will be suspended, and parking will be banned on the seaward side between the Lifeboat Station and the breakwater itself.
Framework of new Sea Services Agreement ready, says minister
Attorney General says he's stepping down
Road closures in two towns for running event this week
Six weekend ferry crossings could face disruption
President of Tynwald announces retirement
Police close Mountain road
Fuel firm says "fingers crossed" for calmer energy costs
Ring doorbells will need data protection registration - but shouldn't cost you money