Manx Utilities says motorists face six months of misery as it improves the capital's sewage system.
Work on a 23-week project on the Old Castletown Road will start on Thursday.
Kewaigue's pumping station will be replaced, and work will take place on the Old Castletown Road and Heron & Brearley brewery site.
There'll be a number of road closures and traffic restrictions between Thursday, April 3 and Wednesday, April 16.
MHK sues attorney general and returning officer over election votes
Islanders reminded to keep challenging domestic abuse beyond October
Peel fireworks kicks off the Island’s bonfire season this Friday
Yellow weather warning for coastal overtopping remains in force today
Nominations open for 10 local authority by-elections
MHK wants answers on support for home-schooled children
Weather warning for tonight and tomorrow
Mountain Railway damaged by gales