A section of the Mountain Road is now closed until Midday, after a wall collapsed.
The DOI says the route between Ramsey and the Bungalow won't be accessible because of the 'hazardous obstruction'.
The closure is due to be in place until 12 - but could be longer as the department says the condition and safety of the road will need to be reviewed.
Meanwhile, access to the Mountain Road from the Tholt-Y-Will is unaffected.
Framework of new Sea Services Agreement ready, says minister
Attorney General says he's stepping down
Road closures in two towns for running event this week
Six weekend ferry crossings could face disruption
President of Tynwald announces retirement
Police close Mountain road
Fuel firm says "fingers crossed" for calmer energy costs
Ring doorbells will need data protection registration - but shouldn't cost you money