The Private Patients Unit at Noble's Hospital will close on January 7.
The closure, announced by Health and Social Care Minister David Ashford in October, will see in-patient and day case private medical treatment temporarily suspended.
It comes as part of a wide-ranging review by the DHSC and overhaul aimed at 'modern private medical services and facilities for the future'.
Private consultations at Noble's will continue, and diagnostic investigations such as blood tests, radiological imaging and endoscopy will continue to be provided for patients.
The department added a team at the hospital is regularly meeting consultants to plan for the private work to continue in the New Year.
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