The Mountain Road will be subject to closures at the weekend and on several days next week.
The A18 between Barrule Park in Ramsey and the Creg-ny-Baa will close on Sunday (September 22) between 9.30am and 4pm whilst the IOM Cycle Challenge takes place.
Following that, the section between Ramsey Hairpin and the Creg-ny-Baa will be cordoned off each day between 9.30am and 4.30pm from Monday, September 23, to Wednesday, September 25 whilst road lining work is carried out.
For the latter works, should there be poor weather on those days, the road lining will instead take place from October 1 to October 3.
Manxman sailings in doubt from tomorrow
Car falls down steep bank on Mountain Road
Panic over - Mcdonald's reopens at 11am tomorrow
Police say beat it to cars illegally parked during MJ tribute act
No dedicated prostate cancer screening programme, despite over 1,200 referrals
Minister says GP waiting times have improved, but delays still impact A&E
Crash closes section of the Mountain Road
Island's prison nears full capacity