The Department of Infrastructure says Braddan Bridge will be one-way as it carries out work later this month.
After two sets of work outside Braddan Church so far this year, the DOI says it needs to do work on a manhole between the two roundabouts at Braddan.
As a result, traffic will be one-way towards Douglas between Braddan Road and Saddle Road.
The restrictions will run overnight from 6:30pm on Wednesday, April 16 to 8am on Thursday, April 17.
Peel ready for bonfire and fireworks later
Government: "UK never told us about child murderer"
Farm shop's newest worker needs your name suggestions
Bus Vannin gives update on staffing problems and routes affected today
Toilets vandalised for fourth time in a month
Poppy gets fur-ever home after sparking rescue operation in Douglas
Council gets eight complaints about James Brown in six months
More bus staffing problems this weekend