Manx Care says it's top 10 drugs are anticoagulants, diabetes treatments and inhalers.
A Freedom of Information request asked for the 10 most-prescribed medicines along with their total cost last year.
In its response, Manx Care said it spent just under half a million pounds on prescriptions for Apixaban, which prevents blood clots.
The list also shows it spent £268,608 on 3,792 diabetes sensors.
Report shows growth in government workforce
Can you translate Filipino for court?
Commissioner worried over Ramsey flood wall design
AG's chambers wrongly blocked FOI response, says info commissioner
Navy ship off Island's coast
'Harrods of the West' to reopen in April
Mountain Road closed on 68 days last year
Terry’s Tato’s owner named 2026 Customer Service Champion