Airline Logan air have confirmed they will not be continuing either the Edinburgh or Glasgow routes after June of this year.
It's more bad news for local airport users after Flybe withdrew its Gatwick service.
Loganair currently operate a single daily service six days a week to both destinations under a franchise agreement with Flybe.
They have cited declining passenger figures for the move.
Loganair have been operating services from Edinburgh and Glasgow since 2004, however, over the last 3-4 years whilst their revenue has remained static, their operating costs have increased by around 20%.
Weather postpones council's Easter fun day
Seven ferry crossings hit by water levels and dredging issues in Douglas
Sam Barks returns to Les Mis in transatlatic tour
DHSC commissioning rapid review of Noble's bed capacity
Progress being made on landmark's new building
Temporary traffic lights on TT course section
All government departments but one within budget
Unclaimed Manx lottery ticket worth £125,000 - is it you?!