Ballasalla Medical Centre has decided to formally hand back its contract at the end of July.
Manx Care is now working with the practice to 'secure the future provision of GP services.'
The health body adds that this news will undoubtedly cause a lot of uncertainty, and plans are being put in place to support patients going forward.
People are being urged not to try and register with another practice at this time, as it would cause issues for other GP surgeries in the south.
At the moment, affected patients will still be able to access their GP service as usual.
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