The Ballamodha straight will be closed for several hours following a crash.
Fire crews from Castletown and Malew station have attended the incident involving two cars.
One casualty was cut out of the car, with crews also helping the ambulance service.
It’s not yet known when the route will reopen - it’s currently closed from Solomon’s Corner to the St Marks junction.
Commissioners worried about speed cameras on new 20mph signs
Could new 20mph sign poles be used to mount speed cameras in future?
Formula One Classic TT cancelled
MGP organisers say Friday's race schedule has been tweaked after delays to today's action on the Mountain Course.
Course due to close at 6pm, say police
Police say roads around the Mountain Course are due to close at 6pm for racing.
How can historic buildings be more eco-friendly?
How can historic buildings contribute towards net zero emissions?
Racing delayed again, with schedule update "imminent"
Race organisers say there's a further delay to today's racing.
MHK asks about support for electrical retailers over tip charges
An MHK is pressing the government about supporting electrical retailers over charges for disposing waste at Civic Amenity Sites.
Tyranno-pour-us: rain wrecks T Rex run
A huge gathering of dinosaurs in Peel has been cancelled - because of rain rather than asteroids!
Three-legged race record attempt cancelled due to lack of interest
An attempt to smash the world record for the world's biggest three-legged race has been cancelled.
