Manx Utilities says motorists face six months of misery as it improves the capital's sewage system.
Work on a 23-week project on the Old Castletown Road will start on Thursday.
Kewaigue's pumping station will be replaced, and work will take place on the Old Castletown Road and Heron & Brearley brewery site.
There'll be a number of road closures and traffic restrictions between Thursday, April 3 and Wednesday, April 16.
How much has the Department of Infrastructure claimed for property damage?
How many times has the Department of Infrastructure claimed money from others for property damage?
Visa fraudster convicted in Isle of Man immigration scam
The Department of Home Affairs has welcomed the conviction of 25-year-old Sagar Joon.
Crowds gather for Maccies re-opening after £1.6m upgrade
Crowds have been flocking to the grand re-opening of McDonald's this morning.
MHK questions wages of 1,500 extra workers
How many of the 1,500 extra people in work since 2021 are on less than £25,000 per year?
Manxman sailings cancelled today
This afternoon’s Manxman sailings have been cancelled due to the incoming bad weather.
New parent employment rights to start this Saturday
The Department of Enterprise says from November 1, parents will get stronger support with new shared parental and bereavement leave rights.
70% of cars fail police winter roadside checks
Police carried out their first roadside checkpoint last night, as part of 'Operation Uplift'.
Festival of Remembrance at the Villa next month
A special concert will be held to mark the 80th anniversary of WWII next month.
