Infrastructure says work on a road behind Douglas promenade will mean shutting the route for up to six weeks.
Resurfacing work sets underway on Palace Road from today, with the lower part up to Falcon Cliff closing completely.
The upper section will remain two-way, with temporary traffic lights and a 20mph speed limit in place.
The department say it expects the scheme to take between four and six weeks to finish.
Fuel price hit may last into winter, says government
Further temporary speed limits on TT course
Western homes to be without water tomorrow
Co-Op ordered to hand over evidence in blind worker's tribunal
Who'll be getting meningitis vaccines?
New atlas shows dramatic fall in Island birth rate
Autocar lavishes praise on Island's roads
Super Unleaded hits almost 165p a litre