Police say St Marks Road is closed again after a second crash this morning.
Earlier, officers closed the road in Ballasalla for around an hour after a crash.
However, they say a second incident near Clenagh Road means the route is now shut again.
Officers say drivers should avoid the area if possible.
Repairs on Peel Power Station to get underway
Manx Care doctor survey to be discussed by Tynwald
Weather warning for snow tonight
MHK queries safety at primary school in Ballabeg
Gales put two ferry sailings at risk tonight
Should the Island throw a birthday party for Barry Gibb?
Warning issued over icy roads
High ground could see 4 inches of snow on Saturday night