21 jobs are to go at Santander.
The bank says staff numbers will be cut from 53 to 32 full time roles.
It's after a review by Santander UK PLC which wants the Island branch to become less complicated and more efficient.
Redundancies are likely if staff do not decide to relocate or if redeployment cannot be found.
The operation will be scaled back throughout this year.
Two more schemes backed by government fund
Island to get Bikesafe scheme for first time
Jurby Junk's Stella dies aged 90
No plans to publish UK's assisted dying letters
Burst water main disrupts Onchan supply
Government advice following spike in data breaches
Plans for four-foot flood walls at Ramsey harbour
Garage blaze in the early hours of this morning