The police says that the Mountain Road, and roads in Onchan and Laxey are impassable.
Officers say that snow and ice sheets make the roads dangerous to use.
The Department of Infrastructure is working to improve conditions.
But it asks drivers to consider whether their drive is necessary in the mean time.
Is Manx politics taught in schools?
Poor survey results still show improvements, says Manx Care
Firefighter taster sessions tonight
Council says less than 2% of homes are empty
Tender process on sea wall to start this year, says DOI
Firefighters tackle 'severe' garage blaze this morning
Exhausted reserves forced 23.6% rate rise, say commissioners
Weather warning for heavy rain today