The accident happened last night (Wednesday) at Ballacobb near Ballaugh.
The Fire & Rescue Service said the incident involved one car which had rolled onto its roof.
The occupants were free of the car when the fire service arrived.
They were treated at the scene by paramedics before being taken to hospital.
Police closed the road for several hours after the crash which happened at around 20:00.
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Port St Mary goes to the polls
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Minister hopes air traffic problems now solved
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Poyll Dooey march planned for the weekend
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Commissioner accused of data breaches
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Cat lands man in court over ammo offences
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