The accident happened last night (Wednesday) at Ballacobb near Ballaugh.
The Fire & Rescue Service said the incident involved one car which had rolled onto its roof.
The occupants were free of the car when the fire service arrived.
They were treated at the scene by paramedics before being taken to hospital.
Police closed the road for several hours after the crash which happened at around 20:00.
Colby Glen path shut until next April
A popular footpath in the south of the Island will remain closed until next April.
If you Trick Or Treat, don't trouble the street!
If you're going trick or treating this Hop-tu-Naa, police are warning you not to get carried away.
German newspaper says hello from the Island - and Queen Victoria
A leading German newspaper is urging its readers to sample the delights of the Isle of Man.
Don't buy electric cars, says Manx salvage firm
A salvage company from the south of the Island has told people not to buy electric vehicles.
Aurora-watchers could be in for Friday treat!
Could the Isle of Man get a celestial lightshow to kick off the weekend?
Peel's pulsing UFO has people perplexed
Did you see the UFO off the Island's west coast last night?
Peel MHK raises future of former care home
The future of a former care home in Peel will be raised by one of the town's MHKs.
Netflix film about Patrick's greatest boxer out in November
One of the Island's most famous residents will be starring in his own Netflix documentary next month.
