The accident happened last night (Wednesday) at Ballacobb near Ballaugh.
The Fire & Rescue Service said the incident involved one car which had rolled onto its roof.
The occupants were free of the car when the fire service arrived.
They were treated at the scene by paramedics before being taken to hospital.
Police closed the road for several hours after the crash which happened at around 20:00.
Budget passes by 21 votes to 10
10 Tynwald members voted against the government's budget today.
Don't park at the Bottleneck tomorrow!
Douglas Council is asking people not to park in the Bottleneck Car Park tomorrow.
Yellow ice warning issued by Met Office
Ronaldsway Met Office has issued a second weather warning today.
Met Office issues amber overtopping warning
Ronaldsway Met Office has issued an amber weather warning for tomorrow.
Two ferry sailings cancelled, two more at risk
Two Steam Packet sailings have been cancelled tonight, with another two at risk tomorrow.
Plans unveiled for new Patrick wetland
The Manx Wildlife Trust has submitted plans to create a new wetland in the west of the Island.
Police looking for witnesses after collision in Ramsey
Police are appealing for witnesses after a crash involving a car and a pedestrian in Ramsey.
Over 21,500 passengers have used the number 8 bus
The Department of Infrastructure says a newly-introduced bus route has seen more than 21,500 people use it since it launched last summer.
