The accident happened last night (Wednesday) at Ballacobb near Ballaugh.
The Fire & Rescue Service said the incident involved one car which had rolled onto its roof.
The occupants were free of the car when the fire service arrived.
They were treated at the scene by paramedics before being taken to hospital.
Police closed the road for several hours after the crash which happened at around 20:00.
TT grandstand flags were unsafe, says DOI
The Department of Infrastructure says flags at the TT Grandstand have been removed because it's not safe to fly them.
Bus advice issued amid TT racing uncertainty
Bus Vannin's advising people not to hang around if they're waiting to get buses around the TT course this morning.
TT wildfire risk "very high"
The Department of Environment, Food and Agriculture has described the risk of wildfires during TT as "very high".
TT tour will help youngsters in Kyiv
A special trip around the TT course this weekend will help child refugees in Ukraine.
Outrage after Wheelie Konni's burnout reported to police
Fans have reacted with anger and shock after one of the best-known TT visitors was reported to police this week.
Visibility problems at airport
Ronaldsway Airport says its operations continue to be plagued by fog and mist today.
TT organisers announced delay to today's race schedule
The clerk of the course has announced a one-hour delay to today's racing schedule.
Multiple riders stopped for offences on Mountain Road
Police say they stopped a rider for going the wrong way on the Mountain Road today.
