The accident happened last night (Wednesday) at Ballacobb near Ballaugh.
The Fire & Rescue Service said the incident involved one car which had rolled onto its roof.
The occupants were free of the car when the fire service arrived.
They were treated at the scene by paramedics before being taken to hospital.
Police closed the road for several hours after the crash which happened at around 20:00.
12-seater ferry to Cumbria coming soon?
A new "minibus" ferry could soon be running from Cumbria to the Isle of Man.
Lifeboat launched to help fishing boat
Port St Mary's lifeboat crew was called to help a fishing boat earlier.
Smartmeter alert problem now fixed, says Manx Utilities
Manx Utilities says it's now solved problems that sent users false alerts about their smartmeter balance.
Merchant Navy Day marked this week
Merchant Navy Day will be marked on Island with a remembrance service for those who lost their lives at sea.
Filipino festival planned for Laxey
A huge celebration of the Island's Filipino community will take place in Laxey later this year.
Glen Maye requisition meeting scheduled
A requisition meeting will be held in Glen Maye next month.
Political satire is coming to the Gaiety Theatre in Douglas next week, just in time to poke fun at the general election.
Viking longboat races today
Viking races will finally get underway in Peel today - after a six-week delay.
