Slieau Whallian Road in German has been closed because of a landslip.
The Department of Infrastructure says it's shut between the junctions with the Patrick Road and Ballanass Road in Lower Foxdale.
The closure's in place until 8am on Wednesday, February 11.
No pedestrians or cars will be allowed along the route, though emergency access will be maintained.
Peel MHK raises future of former care home
Netflix film about Patrick's greatest boxer out in November
Three buses won't run, eight more at risk today
Former chief minister to ask first question of new parliament
New children's soft-play coming to tearooms in Laxey
More dates added to food hygiene training
Peel Secret Santa scheme brings hope to Island families this Christmas
Own Homes approaches 1,000 pre-registrations on the Isle of Man