All Year 7 pupils at QEII High School and their households are being told to self-isolate immediately.
It comes after government confirmed two pupils in that year group at the Peel school have tested positive for Covid-19.
Officials say unless anyone affected has Coronavirus symptoms they should not contact 111 at this time.
Instead affected households are asked to quarantine and await further instructions.
Vegan beauty salon up for sale
Committee says more housing needed for young people
Half of broken defibs now working
Cider microbrewery planned for Ballasalla
Covid wrongful arrest and torture claims thrown out by court
Tree fellers to close part of TT course on Thursday
Manx Utilities wants contractors for HQ refurb
Business needed for Peel coffee shop's 'new chapter'