Peggy's nightclub on Douglas promenade will close this autumn.
The announcement was made on social media last night.
Owners say they want to leave in their "prime with heads held high".
The popular Douglas venue, which started as a pop-up in 2018, will close on 2 October.
It is the second bar in the Isle of Man to close this month.
On 9 August Bar Logo in Ramsey announced it was shutting with immediate effect after being hard-hit by the pandemic.
Full Moon Festival returns this weekend
The return of a popular music festival this week will see a temporary speed limit on one of the key roads into Douglas.
Castletown gets new homes for endangered Swifts
Four new Swift nesting boxes have been installed in Castletown Square.
Paralysed TT star gives thanks for support
A rider who was left partly paralysed by a crash during TT has thanked everyone for their support.
'Good Times' are heading to the Villa Marina this autumn
Music legends Nile Rodgers and CHIC are set to perform at the Villa Marina this September.
Public consultation on NHS weight loss jabs considered
A public consultation on offering weight loss injections through the NHS is still being considered according to Cabinet Office Minister David Ashford.
Another talk on armed policing tonight
There's another chance to find out more about armed policing tonight.
IOM Scooter Rally returns this weekend
This weekend sees the 2026 IOM Scooter Rally return, with around 300 two wheeled visitors expected to the Island.
Sam Barks to return home for charity concert
Manx singer and actress Samantha Barks will return to the Isle of Man this November for a special candlelit concert in aid of Hospice Isle of Man.
