Police say a pedestrian has died after an incident in Onchan in the early hours of this morning.
Officers say it happened at around 3.30am on Whitebridge Road.
An investigation has been launched after one person later died in Noble's Hospital.
Whitebridge Road has now reopened after being closed since the incident.
Police are urging the public to refrain from public judgement or assumption and respect the family and friends of the person who died.
Roads to close for music festival this weekend
How long do mental health patients stay in Manannan Court?
Could you take over this former restaurant?
Framework of new Sea Services Agreement ready, says minister
Attorney General says he's stepping down
Road closures in two towns for running event this week
Six weekend ferry crossings could face disruption
President of Tynwald announces retirement