The Mountain Road will close each day for maintenance work next week.
The Department of Infrastructure says the route will shut from 9am to 5pm from Monday, July 28 to Friday, August 1.
Workers will be trimming verges and felling two trees.
A roadside wall near the Gooseneck will also be rebuilt after a car crashed into it during this year's TT.
Northern bus services to be raised in Keys
Ben out of service for maintenance work this week
Richmond Hill closed again tonight for work
October warmer and sunnier than usual, says Met Office
MHK queries cost of Liverpool awards trip
DOI says it has 20 empty public sector homes
Marquee plan submitted by Milntown Estate
Fire crews called to free driver from crashed car