The Manx Emergency Doctors Service will close overnight for a period of 12 weeks.
Manx Care says the service will be unavailable between the hours of midnight and 8am from January 8 to the end of March.
The change is due to recent staffing issues and a reduction in demand during these hours.
During the closure there will be an on-call GP available to support the Ambulance Service and Hospice if required.
The health body also says from mid-January there will be an extra locum GP during the day.
Warning over beach work in Douglas next week
Racer appeals for return of missing awning
Charity worker announces Malew election bid
Woman releases fundraising poetry book
Castletown hosts tin bath racing
New Deputy High Bailiff needed - could it be you?
Mountain Road closed for skateboarding today
Peel ready for huge community sale later