Dr Henrietta Ewart has left her role within the government and intends to retire.
Dr Ewart took up the role of Director of Public Health in December 2016 after serving as interim Director for 18 months.
It comes after David Ashford announced he was stepping down as Treasury Minister and Department of Health and Social Care CEO Karen Malone left her position.
Interim Chief Secretary Caldric Randall says the role of Director of Public Health will be advertised in due course, and thanks Dr Ewart for her commitment and expertise.
Sarah Astin breaks Isle of Man women’s marathon record in Seville
DOI declines to reveal charity land lease costs in Ramsey
Ballakilpheric Road shuts tomorrow
Peel Carnival needs you!
Commissioners looking for new clerk
Nobody charged for paper Manx Utilities bills, says chair
Should cohabiting couples get married tax breaks?
Repairs on Peel Power Station to get underway