The Mountain Road has shut this morning after a crash.
Police say the route is closed between the Ramsey Hairpin and the Bungalow after an incident earlier involving one vehicle.
It happened just after 7am.
Drivers are being advised to use alternate routes.
Road closures in two towns for running event this week
Six weekend ferry crossings could face disruption
President of Tynwald announces retirement
Police close Mountain road
Fuel firm says "fingers crossed" for calmer energy costs
Ring doorbells will need data protection registration - but shouldn't cost you money
Hospice UK head calls Island cuts "cack-handed" ministerial muddle
Bus drivers voting on "final offer" from government