Africa House, on Woodbourne Road in Douglas is on fire.
In a post on social media, police have confirmed Emergency Services are at the scene.
People are asked to avoid the area whilst a section of Woodbourne Road is currently closed between the junction of Albany road and York road traffic lights.
Two more schemes backed by government fund
Island to get Bikesafe scheme for first time
Jurby Junk's Stella dies aged 90
No plans to publish UK's assisted dying letters
Burst water main disrupts Onchan supply
Government advice following spike in data breaches
Plans for four-foot flood walls at Ramsey harbour
Garage blaze in the early hours of this morning