The Mountain Road is currently closed between Brandywell and the Creg Ny Baa.
Police have confirmed the closure following a crash earlier this morning.
Pictures have been circulating of a vehicle on fire, with emergency services at the scene.
The department of infrastructure has confirmed the closure will be in place until at least 12.40pm this afternoon.
Nobody charged for paper Manx Utilities bills, says chair
Should cohabiting couples get married tax breaks?
Repairs on Peel Power Station to get underway
Manx Care doctor survey to be discussed by Tynwald
Weather warning for snow tonight
MHK queries safety at primary school in Ballabeg
Gales put two ferry sailings at risk tonight
Should the Island throw a birthday party for Barry Gibb?