Vanessa Walker passed away following a period of illness.
Manx Care has confirmed Vanessa was diagnosed with cancer in February 2021 and "fought her illness with incredible strength, grace and determination".
Manx Care has offered its sincere condolences to Vanessa’s family and friends.
A spokesman said the Non-Executive Director of Manx Care was a "remarkable asset" and "a nurse, with empathy and care at the centre of everything she did".
The Board says they have lost a "great colleague and the island has lost a great friend.'
Weather warning for snow tonight
MHK queries safety at primary school in Ballabeg
Gales put two ferry sailings at risk tonight
Should the Island throw a birthday party for Barry Gibb?
Warning issued over icy roads
High ground could see 4 inches of snow on Saturday night
Mountain Road unlikely to open before Monday
Yellow warning for freezing temperatures tonight