Airline Logan air have confirmed they will not be continuing either the Edinburgh or Glasgow routes after June of this year.
It's more bad news for local airport users after Flybe withdrew its Gatwick service.
Loganair currently operate a single daily service six days a week to both destinations under a franchise agreement with Flybe.
They have cited declining passenger figures for the move.
Loganair have been operating services from Edinburgh and Glasgow since 2004, however, over the last 3-4 years whilst their revenue has remained static, their operating costs have increased by around 20%.
Balladoole's re-use sheds on the agenda in Tynwald
Yellow weather warning issued over snow and ice tonight
Steam Packet carried 680,000 passengers last year
Roof work to shut Castletown shopping street
Church unveils plans to modernise facilities
Are Mountain Road closures harming Ramsey?
No whey! Creamery says goodbye to much-loved butter
Roofing Outlaw plans Isle of Man franchise