Airline Logan air have confirmed they will not be continuing either the Edinburgh or Glasgow routes after June of this year.
It's more bad news for local airport users after Flybe withdrew its Gatwick service.
Loganair currently operate a single daily service six days a week to both destinations under a franchise agreement with Flybe.
They have cited declining passenger figures for the move.
Loganair have been operating services from Edinburgh and Glasgow since 2004, however, over the last 3-4 years whilst their revenue has remained static, their operating costs have increased by around 20%.
Crogga still owes the Isle of Man Government money
DoI says works at Liverpool ferry terminal will take longer
Over 50 employment tribunals outstanding at the DoI
Free period products bill raises cost concerns for MHKs
Key road in Ramsey to re-open early this afternoon
Want to start training to become a nurse?
Appeal launched after fly-tipper filmed dumping rubbish
Prepare your pets for Bonfire Night, says Manx charity
