The Company Registry says more than 400 companies will be removed in eight weeks' time.
Registrar General Edward Clague released a list of Island-registered firms that will come off the list in two months.
They include the former owner of Isle of Man Newspapers, the Mannin Media Group, and Hawkins BBQ, which ran a well-known catering van until last January.
In total, 424 companies will be removed unless representations are made to the registry.
Northern tip's re-use area to open again next month
Mountain Road closed for TT sign removal
Decision on Summerland campaigners' appeal this week
More works on Old Castletown Road this week
Airport says flights may be affected by morning's fog
Could the Grandstand be getting a new entrance plaza?
Caine to defend seat in general election
June sitting of Tynwald to take place today