Eastern airways have this morning announced that they will be withdrawing their two routes from the island.
They will cease operating flights from the Isle of Man to Birmingham and Newcastle at the end of this month.
The Birmingham route is still covered by Flybe and the airport are trying to get an airline to take over the Newcastle one.
The collapse of the routes is being put down the current economic downturn.
Some journeys have been operating recently with only a third of the plane filled.
Harbour 2 Harbour entries now open
Castle Rushen designs 'ongoing', says minister
Two sailings cancelled, a further two at risk
Will the airport get a facelift soon?
Clocks go forward tonight!
Possible oil price hikes prompt Keys question
Government considers tourism tax to boost hospitality
US visitors need "increased caution" visiting Island, says State Department