Manx Care's issued advice after talks between drivers and the government failed to avert this week's bus strike.
It says those with upcoming appointments should plan alternative arrangements if they were planning on travelling by bus.
It adds you can also reschedule your appointment by contacting the department that issued it as soon as possible.
And the organisation is reassuring people the Bus Vannin Patient Transport Service will operate as normal, along with the Adult Social Care and Learning Disability Transport Services.
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