The Mountain Road will close for 6 weeks from 28 February.
It's as work gets underway in preparation for this year's TT.
The closure was supposed to take place last August but was pushed back until 2022 following consultation with both stakeholders and the public.
Ramsey to the Bungalow will be shut until March 28, followed by the entire mountain route for a further three weeks - closures are thought to be lifted by April 15 at the latest.
Snaefell and the Victory Café will be accessible for the duration of the works, as will the Creg-Ny-Baa.
Meanwhile, The DOI has confirmed the road will be accessible between the Bungalow and Creg-ny-Baa at peak times.
Police still looking for stolen car from Douglas
Planning submitted for new mobile classrooms for two schools
Infrastructure Minister says department is dealing with boy racers
Charity holding suicide prevention training in June
Manx resident caught-up in Georgian protests
Hebridean Sky cruise ship arrives today
Number of children who committed crimes after police intervention not known, says MHK
Biker seriously injured after van pulled out, Court hears
